منابع مشابه
Vitamin D and colon carcinogenesis.
Colorectal cancer is the third most commonly occurring cancer in the United States and accounts for approximately 11% of cancer deaths. Many epidemiological studies have shown an association between dietary factors, including calcium and vitamin D, and the incidence of colon cancer. Recently the Calcium Polyp Prevention Study demonstrated that calcium supplementation can reduce the recurrence o...
متن کاملInhibitory effect of vitamin A on carcinogenesis.
In two experiments, f3-carotene applied to mice initiated with 7,12-dimethylbenz[a]anthracene (DMBA), concomitantly with croton resin and croton oil, increased tumor incidence by 58 and 29%. In the same experiments, retinyl acetate reduced tumor incidence by 76 and 29%. Retinol in one experiment reduced the number of papillomas by 75%. f3-lonone, squalene, and isoprene had little or no effect o...
متن کاملStudying humane endpoints in a rat model of mammary carcinogenesis
Objective(s): The present work intended to clearly define the most adequate humane endpoints in an experimental assay of mammary carcinogenesis in rats. Materials and Methods: Animals were observed twice a day; all parameters were registered once a week and the euthanasia endpoints were established in order to monitor the animal welfare/...
متن کاملSuppression of colonic carcinogenesis by vitamin D in rats.
Colon cancer is the second most important cancer in developed countries. Increased intake of dietary fat is considered to be responsible for this phenomenon, since high fat diets increase the secretion of bile acids, which act as a colonic tumor promoterClj. On the other hand, epidemiological studies suggest that vitamin D plays a protective role against colorectal cancers(2J. This was supporte...
متن کامل1α,25(OH)₂-vitamin D and a nongenomic vitamin D analogue inhibit ultraviolet radiation-induced skin carcinogenesis.
Exposure to ultraviolet radiation (UVR) can lead to a range of deleterious responses in the skin. An important form of damage is the DNA photolesion cyclobutane pyrimidine dimer (CPD). CPDs can be highly mutagenic if not repaired prior to cell division and can lead to UV-induced immunosuppression, making them potentially carcinogenic. UVR exposure also produces vitamin D, a prehormone. Differen...
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ژورنال
عنوان ژورنال: The American Journal of Cancer
سال: 1936
ISSN: 0099-7374
DOI: 10.1158/ajc.1936.84